北京大学师资介绍--生命科学院昌增益

 

　　昌增益

 

　　基本简介：

　　昌增益，北京大学教授、博士生导师。萍乡荷尧镇人。1965年出生，16岁考入华东师范大学，20岁通过CUSBEA项目公派赴美留学，27岁毕业于美国贝勒医学院生物化学系，获博士学位，之后三年为美国休斯顿医学研究所博士后研究员，30岁回国后在清华大学任教，32岁获国家杰出青年科学基金奖。曾任清华大学生物系教授,博导、清华大学医学院院长助理(院长为吴阶平院士)、“蛋白质科学”教育部重点实验室副主任、清华大学生物化学与分子生物学研究所副所长(1998-2003)。现任北京大学生命科学学院教授、博士生导师(2003年9月开始)。现任国际蛋白质协会刊物Protein Science(蛋白质科学)刊物编委。

　　研究领域：

　　1. 生物的胁迫响应，包括衰老和休眠现象的分子机制 (Stress responses of living organisms: including the molecular mechanism of aging and dormancy)

　　2. 生物体内蛋白质-蛋白质相互作用的发生情况、机制、及生物学意义 (Mechanism and biological significance of protein-protein interactions)

　　学术兼职：

　　国际蛋白质学会现任主席Arthur G. Palmer博士(美国哥伦比亚大学教授)代表其现任执委会(executive council)于2008年6月12日来函，正式任命北京大学生命科学学院副院长、北京大学跨院系蛋白质研究中心主任昌增益教授为该组织执委，任期为3年(2008年-2011年)。该组织的执委会一般由15人组成，包括该组织的前任主席，现任主席和候任主席等。执委会每年开会两次，是该组织的最高议事和权利机构。

　　代表性论文：

　　1. Weizhe Hong, Ye E. Wu, Xinmiao Fu and Zengyi Chang , Chaperone-dependent mechanisms for acid resistance in enteric bacteria , Trends in Microbiology , 2012 , 20:328-335 , invited review by the editor

　　2. Dickinson, B. C., Tang, Y. Chang, Z. and Chang, C. J. , Development of a Nuclear-Localized Fluorescent Probe for Hydrogen Peroxide and Applications to the Study of Sirtuin-Mediated Oxidative Stress Responses in vivo , Chem. Biol , 2011 , 18:943-948 , corresponding author

　　3. Wu, S. Ge, X. Lv Z., Zhi Z., Chang, Z. and Zhao, X. S , Interaction between Bacterial Outer Membrane Proteins and Periplasmic Quality Control Factors: A Kinetic Partitioning Mechanism , Biochem. J. , 2011 , 438:505-511 , corresponding author

　　4. Xiaodong Shi, Zhao Wang, Linxuan Yan,Anastasia N. Ezemaduka, Guizhen Fan, Rui Wang, Xin-Miao Fu, Chang-Cheng Yin, Zengyi Chang , small heat shock protein AgsA forms dynamic fibrils , FEBS Letters , 2011 , 585:3396-3402

　　5. Zhang, M., Lin, S. Song, X. Liu, J. Fu, Y. Ge, X. Fu, X. Chang, Z. Chen, P. R. , A genetically incorporated crosslinker reveals chaperone cooperation in acid resistance, , Nat. Chem. Biol. , 2011 , 7:671-677. , corresponding author and cover article

　　6. Zengyi Chang , Posttranslational modulation of Biological Activities of Molecular Chaperones , Science in China Series C: Life Sciences , 2009 , 52(6)：515-520. , [Full Text] , Invited Critical Review

　　7. Zengyi Chang , The CUSBEA Program: Twenty Years Later , IUBMB Life , 2009 , 61:(6)555-565 (feature article)

　　8. FENG Yongjun, ZHANG Meng, HU Mingxi, ZHENG Jie, JIAO Wangwang & CHANG Zengyi , Disassembly Intermediates of RbsD Protein remain Oligomeric despite the loss of an intact secondary structure , Sci. China Ser. C-Life Sciences , 2009 , in press

　　9. Yunbiao Wang, Anastasia N. Ezemaduka, Yan Tang and Zengyi Chang , Understanding the Mechanism of the Dormant Dauer Formation of C. elegans: From Genetics to Biochemistry , IUBMB Life , 2009 , 61(6)：607-612. , invited critical review

　　10. Jiang, J.S., Zhang, X. F., Chen, Y., Wu, Y., Zhou, Z. H., Chang, Z., Sui, S.F. , Activation of DegP Chaperone-Protease via Formation of Large Cage-like Oligomers upon Binding to Substrate Proteins , Proc. Natl. Acad. Sci. USA , 2008 , 105(33)：11939-11944. , 通讯作者(corresponding author)

　　11. Jiao, W., Hong, W., Li, P., Sun, S., Ma, J., Qian, M., Hu, M., and Chang, Z. , The Dramatically Increased Chaperone Activity of Small Heat Shock Protein IbpB is Retained for an Extended Period of Time after the Stress Condition is Removed , Biochem. J. , 2008 , 15;410(1)：63-70. , [Abstract]

　　12. Liu, C., Mao, K., Zhang, M., Sun, Z., Hong, W., Li, C., Peng, B., and Chang, Z. , The SH3-Like Domain Switches Its Interaction Partners to Modulate the Repression Activity of Mycobacterial Iron-Dependent Transcription Regulator (IdeR) in Response to Metal Ion Fluctuations , J. Biol. Chem. , 2008 , Vol. 283, Issue 4, 2439-2453 , [Abstract] , [Full Text]

　　13. Wu, Y., Hong, W., Zhang, L., and Chang, Z. , Conserved Amphiphilic Feature Is Essential for Periplasmic Chaperone HdeA to Support Acid Resistance in Enteric Bacteria , Biochem. J. , 2008 , 412:389-397. , [Abstract]

　　14. 马静， 葛熙、昌增益 , 蛋白质功能研究：历史、现状和将来 , 生命科学 , 2007 , 19(3)：294-300 , 应邀综述

　　15. Feng, Y., Jiao, W., Fu, X., and Chang, Z. , Stepwise Disassembly and Apparent Non-stepwise Reassembly for the Oligomeric RbsD Protein , Protein Science , 2006 , 15(6)：1441-1448.

　　16. Fu, X., and Chang, Z , Identification of bis-ANS binding sites in Mycobacterium tuberculosis small heat shock protein Hsp16.3: Evidences for a two-step substrate-binding mechanism , Biochem. Biophys. Res. Commun. , 2006 , 349:169-171.

　　17. Hong, W., Jiao, W., Hu, J., Zhang, J., Liu, C., Fu, X., Shen, D., Xia, B., and Chang, Z. , Periplasmic protein HdeA exhibits chaperone-like activity exclusively within stomach pH range by transforming into disordered conformation , J Biol Chem. , 2005 , Vol. 280, Issue 29, 27029-27034 , [Abstract] , [Full Text]

　　18. Jiao,W., Qian, M., Li, P., Zhao, L., and Chang, Z. , The essential role of the flexible termini in the temperature-responsiveness of the oligomeric state and chaperone-like activity for the polydisperse small heat shock protein IbpB from Escherichia coli , J Mol Biol. , 2005 , Volume 347, Issue 4, 8 April 2005, Pages 871-884 , [Full Text]

　　19. Fu, X., Zhang, H., Zhang, X., Cao, Y., Jiao, W., Liu, C., Song, Y., Abulimiti, A., and Chang, Z. , A dual role for the N-terminal region of Mycobacterium tuberculosis Hsp16.3 in self-oligomerization and binding denaturing substrate proteins , J Biol Chem. , 2005 , Vol. 280, Issue 8, 6337-6348 , [Abstract] , [Full Text]

　　20. Fu, X. and Chang ,Z. , Phylogenetic and biochemical studies reveal a potential evolutionary origin of animal small heat shock proteins from bacterial class A , J. Mol. Evol., , 2005 , 62:257-266.

　　21. Fu, X., Zhang, X., and Chang, Z. , 4'-dianilino-1,1'-binaphthyl-5,5'-sulfonate (bis-ANS)， a novel molecule having chaperone-like activity , Biochem Biophys Res Commun., , 2005 , 329:1087-1093.

　　22. Jiao, W., Li, P., Zhang, J., Zhang, H., Chang, Z. , Small Heat Shock Proteins Function in the Insoluble Protein Complex , Biochem Biophys Res Commun., , 2005 , 335(1)：227-231.

　　23. Zhang, H. Fu, X. Jiao, W., Zhang, X., Liu, C., and Chang, Z. , The association of small heat shock protein Hsp16.3 with the plasma membrane of Mycobacterium tuberculosis: dissociation of oligomers is a prerequisite , Biochem Biophys Res Commun., , 2005 , 330:1055-1061.

　　24. Zhang, X.,Fu, X., Zhang, H., Liu, C. Jiao, W., and Chang, Z. , Chaperone-like Activity of β-Casein , Interna. J. Biochem. Cell Biol., , 2005 , 37:1232-1240.

　　25. Liu Y., Fu, X., Shen, J., Zhang, H., Hong, W., and Chang, Z. , Periplasmic proteins of Escherichia coli are highly resistant to aggregation: reappraisal for roles of molecular chaperones in periplasm , Biochem Biophys Res Commun. , 2004 , Volume 316, Issue 3, 9 April 2004 , [Full Text]

　　26. Liu Y., Fu, X., Shen, J., Zhang, H., Hong, W., and Chang, Z. , Periplasmic proteins of Escherichia coli are highly resistant to aggregation: A reappraisal for roles of molecular chaperones in periplasm , Biochem Biophys Res Commun. , 2004 , 316(3)：795-801.

　　27. Liu, C. He., Y. and Chang Z. , Truncated hemoglobin of Mycobacterium tuberculosis: The oligomeric state change and the interaction with membrane components , Biochem Biophys Res Commun. , 2004 , 316:1163-1172.

　　28. 昌增益，焦旺旺 , 细胞内一种耗能蛋白质降解途径的发现：2004年诺贝尔化学奖工作介绍 , 生物物理学报 , 2004 , 第20卷第6期，第421-425页。 , 应邀综述

　　29. Abulimiti, A., Fu, X., Gu., L., Feng, X., and Chang, Z. , Mycobacterium tuberculosis Hsp16.3 nonamers are assembled and re-assembled via trimer and hexamer intermediates , J Mol Biol. , 2003 , Volume 326, Issue 4, 28 February 2003, Pages 1013-1023 , [Full Text]

　　30. Abulimiti, A., Qiu, X., Chen, J., Liu, Y., and Chang, Z. , Reversible methionine sulfoxidation of Mycobacterium tuberculosis small heat shock protein Hsp16.3 and its possible role in scavenging oxidants , Biochem. Biophys. Res. Commun., , 2003 , 305(1)：87-93.

　　31. Fu, X. Liu, C., Liu, Y., Feng, X., Gu, L., Chen, X., and Chang, Z. , Small Heat Shock Protein Hsp16.3 Modulates Its Chaperone Activity by Adjusting the Rate of Oligomeric Dissociation , Biochem Biophys Res Commun. , 2003 , 310(2)：412-420.

　　32. Gu, L., Abulimiti, A., Li, W., and Chang, Z. , Monodisperse Hsp16.3 nonamer exhibits dynamic dissociation and reassociation, with the nonamer dissociation prerequisite for chaperone-like activity , J Mol Biol. , 2002 , Volume 319, Issue 2, 31 May 2002, Pages 517-526 , [Full Text]

　　33. Dai, H., Mao, Q., Yang, H., and Chang, Z. , Probing the Roles of the Only Universally Conserved Leucine Residue in the Oligomerization and Chaperone-like Activity of Mycobacterium tuberculosis Small Heat Shock Protein Hsp16.3 , J. Protein Chem.,(new name: Protein J.) , 2000 , 19(4)：319-326.

　　34. Yang, H., Huang, S., Dai, H., Gong, Y., Zheng, C., and Chang, Z. , The Mycobacterium tuberculosis small heat shock protein Hsp16.3 exposes hydrophobic surfaces at mild conditions: conformational flexibility and molecular chaperone activity , Protein Sci. , 1999 , 8(1)：174-179 , [Full Text]

　　35. Chang, Z., Primm, T.P., Jakana, J., Lee, I.H., Chiu, W., Gilb ert, H.F., and Quiocho, F.A. , Mycobacterium tuberculosis 16-kDa antigen (Hsp16.3) functions as an oligomeric structure in vitro to suppress thermal aggregation , J Biol Chem. , 1996 , 271(12)：7218-23 , [Abstract] , [Full Text]

　　36. Chang, Z., Choudhary, A. Lathigra, R. and Quiocho, F.A. , The Immunodominant 38-kDa Lipoprotein Antigen of Mycobacterium tuberculosis Is a Phosphate-binding Protein , J. Biol. Chem., , 1994 , 269(3)：1956-1958.

　　37. Chang, Z., Nygaard, P., Chinault, A. C., and Kellems, R. , Deduced Amino Acid Sequence of Escherichia coli Adenosine Deaminase Reveals Evolutionarily Conserved Amino Acid Residues: Implications for Catalytic Function , Biochemistry , 1991 , 30(8)：2273-2280.