北京大学师资介绍--生命科学院柴真

 

　　柴真

 

　　基本简介：

　　柴真，女，北京大学生命科学学院　生理学 教授

　　研究领域：

　　脑损伤和修复过程中神经元钙稳态的调控机制。

　　神经元和胶质细胞低氧损伤或适应的细胞机制。

　　细胞因子及其信号转导途径在体温调节中的作用。

　　代表性论文：

　　1. Sun BN, Lv B, Dong QP, Wang SQ, Chai Z * , Watching moving images specifically promotes development of medial area of secondary visual cortex in rat , Dev Neurobiol , 2009 , 69: 558-567

　　2. Tang AH, Chai Z and Wang SQ* , Dark rearing alters the short-term synaptic plasticity in visual cortex. , Neurosci Lett , 2007 , 206: 799-806

　　3. Wang TF, Zhou C, Tang AH, Wang SQ, Chai Z * , Cellular mechanism for spontaneous calcium oscillations in astrocytes. , Acta Pharmacol Sinica , 2006 , 27: 861-868

　　4. Zhou C, Tai C, Ye HH, Ren X, Chen JG, Wang, SQ, Chai Z * , Interleukin-1β downregulates the L-Type Ca2+ channel activity by depressing the expression of channel protein in cortical neurons. , J Cell Physiol , 2006 , 206: 799-806.

　　5. Zhou C, Ye HH, Wang SQ, Chai Z * , Interleukin-1β regulation of N-type Ca2+ channels in cortical neurons. , Neurosci Lett , 2006 , 403: 181-185.

　　6. Fu Y, Zhang GQ, Hao XM, Wu CH, Chai Z , Wang SQ* , Temperature dependence and thermodynamic properties of Ca sparks in rat cardiomyocytes. , Biophys J , 2005 , 89: 2533-2541.

　　7. Alheim K, Chai Z , Fantuzzi G, Hasanvan H, Di Santo E, Ghezzi P, Dinarello CA, Bartfai T* , Hyperresponsive febrile reactions to IL-1β in IL-1β deficient mice; comparison with cytokine mRNA and protein levels. , Proc Natl Acad Sci USA , 1997 , 94: 2681-2686.

　　8. Chai Z , Alheim K, Lundkvist J, Gatti S, Bartfai T* , Subchromic glucocorticoid pretreatment reversibly attenuates IL-1β induced fever in rats; IL-6 mRNA is elevated while IL-1α and IL-1β mRNAs are suppressed, in the CNS. , Cytokine , 1996 , 8: 227-237.

　　9. Chai Z, Gatti S, Toniatti C, Poli V, Bartfai T* , Interleukin (IL)-6 gene expression in the central nervous system is necessary for fever response to lipopolysaccharide or IL-1β: a study on IL-6-deficient mice. , J Exp Med , 1996 , 183: 311-316

　　10. Loudkvist J, Chai Z , Teheranian R, Hasanvan H, Bartfai T, Jenck F, Widmer U, Moreau JL , A non peptidic corticotropin releasing factor receptor antagonist attenuates fever and exhibits anxiolytic-like activity. , Eur J Pharmacol , 1996 , 309: 195-200.

　　11. Malinowsky D, Chai Z, Bristulf J, Simoncsits A, Bartfai T* , The type I interleukin-1 receptor mediates fever in rat as shown by interleukin-1 receptor subtype selective ligands. , Neurosci lett , 1995 , 201: 33-36.